What is the CAS number for (R)-2-Flurbiprofen?

The CAS number of (R)-2-Flurbiprofen is 51543-40-9.

What is (R)-2-Flurbiprofen (51543-40-9) used for?

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits ?-secretase activity in vitro and, in vivo, it reduces formation of amyloid-ß peptide 1-42 (Aß42) and improves axonal transport in young Aß-plaque free mice but not old mice with existing Aß plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-?B and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.InChI:InChI=1/C12H4F14/c13-7(9(15,16)17,10(18,19)20)5-1-2-6(4-3-5)8(14,11(21,22)23)12(24,25)26/h1-4H

What is the CAS number for (R)-2-Flurbiprofen?

The CAS number of (R)-2-Flurbiprofen is 51543-40-9.

What is (R)-2-Flurbiprofen (51543-40-9) used for?

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.InChI:InChI=1/C12H4F14/c13-7(9(15,16)17,10(18,19)20)5-1-2-6(4-3-5)8(14,11(21,22)23)12(24,25)26/h1-4H

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(R)-2-Flurbiprofen

CasNo 51543-40-9
Purity 99%

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What is the (R)-2-Flurbiprofen ?

(R)-2-Flurbiprofen is , while it's Molecular Formula is C₁₅H₁₃FO₂. (R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

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Q: What is the (R)-2-Flurbiprofen?

(R)-2-Flurbiprofen is , while it's Molecular Formula is C 15 H 13 FO 2 . (R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.