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Enalaprilat


  • CasNo76420-72-9
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What is the Enalaprilat ?

Enalaprilat is white crystalline solid, while it's Molecular Formula is C18H24N2O5. primary hypertension

What is the CAS number for Enalaprilat ?

The CAS number of Enalaprilat is 76420-72-9.

More information of Enalaprilat 76420-72-9 are:

Synonyms

L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-, (S)-;Enalapril acid;Enalaprildiacid;Enalaprilate;Enalaprilic acid;MK 421 diacid;MK 422;N-[1(S)-Carboxy-3-phenylpropyl]-L-alanyl-L-proline;

CAS?Number

76420-72-9

Molecular Formula

C18H24N2O5

Molecular Weight

348.399

Density

1.286±0.06 g/cm3(Predicted)

Melting Point

148-151 °C

Boiling Point

601 °C at 760 mmHg

Flash Point

317.3 °C

HS CODE

2933990090

PSA

106.94000

LogP

1.45490

Pka

pKa 2.30 (Uncertain);3.39 (Uncertain)

What is Enalaprilat (76420-72-9) used for?

Enalaprilat is the diacid active metabolite of enalapril. As an injectable ACE inhibitor, it is reportedly useful in the treatment of uncomplicated accelerated hypertension and hypertensive emergencies. Enalaprilat is more effective in reducing blood pressure in the elderly than in the young, despite the fact that renin activity is lower in old age.

InChI:InChI=1/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1

Articles related to Enalaprilat:

Article

Source

In vitro drug metabolism by human carboxylesterase 1: Focus on angiotensin-converting enzyme inhibitors

Thomsen, Ragnar,Rasmussen, Henrik B.,Linnet, Kristian

, p. 126 - 133 (2014)

Direct monitoring of drug degradation by easy ambient sonic-spray ionization mass spectrometry: The case of enalapril

Amaral, Phellipe H.,Fernandes, Raquel,Eberlin, Marcos N.,Hoeehr, Nelci F.

body text, p. 1269 - 1273 (2012/04/10)

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